BioWorld
Galimedix targeting misfolded amyloid in retinal diseasee
Author: wamrhein
Pharmafocus
Written by wamrhein on . Posted in In the news.
Alzheimer’s disease and age-related macular degeneration – how are they linked and what are the treatments?
Molecular insights into the inhibition of early stages of Aβ peptide aggregation and destabilization of Alzheimer’s Aβ protofibril by dipeptide D-Trp-Aib: A molecular modelling approach
(D-Trp-Aib refers to the same compound as GAL-101)
Written by wamrhein on . Posted in References.
May 2023, International Journal of Biological Macromolecules
The Small Molecule GAL-201 Efficiently Detoxifies Soluble Amyloid β Oligomers: New Approach towards Oral Disease-Modifying Treatment of Alzheimer’s Disease.
Written by wamrhein on . Posted in References.
May 2022, International Journal of Molecular Science
Visual Field Endpoints Based on Subgroups of Points May Be Useful in Glaucoma Clinical Trials: A Study With the Humphrey Field Analyzer and Compass Perimeter
Written by wamrhein on . Posted in References.
August 2021, Journal of Glaucoma
Improved sensitivity of microperimetric outcomes for clinical studies in age-related macular degeneration
Written by wamrhein on . Posted in References.
February 2021, Scientific Reports
The Aβ aggregation modulator MRZ-99030 prevents and even reverses synaptotoxic effects of Aβ1-42 on LTP even following serial dilution to a 500:1 stoichiometric excess of Aβ1-42, suggesting a beneficial prion-like seeding mechanism.
Written by wamrhein on . Posted in References.
November 2020, Neuropharmacology
GAL-101 prevents β-amyloid induced membrane depolarization in two different types of retinal cells. Poster presentation
Written by wamrhein on . Posted in Abstracts.
October 2019, Society for Neuroscience Annual Meeting
Sustained neuroprotective effect of novel Aβ aggregation modulator GAL-101 shown in dry AMD and glaucoma models with transient peak concentrations using eye drops.
Written by wamrhein on . Posted in Abstracts.
July 2019, ARVO Annual Meeting Abstract
MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice
Written by wamrhein on . Posted in References.
May 2015, Neuropharmacology